the effect of endometrial injury on pregnancy rate in frozen-thawed embryo transfer: a randomized control trial
نویسندگان
چکیده
background: implantation failure is one of the most important factors limiting success in ivf treatment. the majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. objective: the purpose of our trial was to explore whether endometrial injury in luteal phase prior to frozen-thawed embryo transfer cycles would improve pregnancy outcomes? materials and methods: we conducted a prospective controlled trial of 93 consecutive subjects at a research and clinical center for infertility. all women were undergone frozen-thawed embryo transfer (fte) cycles. women in the experimental group underwent endometrial biopsy with a pipelle catheter in luteal phase proceeding fet cycle. primary outcomes were implantation and clinical pregnancy rates and secondary outcomes were chemical, ongoing and multiple pregnancy and miscarriage rates. results: 45 subjects who underwent endometrial injury (ei) were compared with 48 control group which did not include any uterine manipulation. there were no significant differences in baseline and cycle characteristics between two groups. the difference in implantation rate was trend to statistically significance, 11.8% in ei group vs. 20.5% in control group (p=0.091). the chemical, clinical and ongoing pregnancy rates were lower in ei group compared with control group but not statistically significant. the multiple pregnancy rate and miscarriage rate also were lower in ei group compared with control group. conclusion: based on results of this study, local injury to endometrium in luteal phase prior to fet cycle had a negative impact on implantation and clinical pregnancy rates.
منابع مشابه
The effect of endometrial injury on pregnancy rate in frozen-thawed embryo transfer: A randomized control trial
BACKGROUND Implantation failure is one of the most important factors limiting success in IVF treatment. The majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. OBJECTIVE The purpose of our trial was to explore whether endometrial injury...
متن کاملEffect of Progesterone Supplementation on Natural Frozen-Thawed Embryo Transfer Cycles: A Randomized Controlled Trial
متن کامل
P-191: A Comparison of The Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-Thawed Embryo Transfer Cycles: A Randomized Clinical Trial
Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradi...
متن کاملa randomized trial to evaluate the effect of local endometrial injury on the clinical pregnancy rate of frozen embryo transfer cycles in patients with repeated implantation failure
objective: repeated implantation failure (rif) is a condition in which the embryos implantation decreases in the endometrium. so, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. materials and methods: in this simple randomized clinical trial (rct), a total of 120 patients were selected. the participants were less than 40 years old, and they are in thei...
متن کاملEffect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial
BACKGROUND Sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. OBJECTIVE The aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate ...
متن کاملeffect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial
background: sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. objective: the aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of reproductive biomedicineجلد ۱۴، شماره ۷، صفحات ۴۵۳-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023